View the review history for ABT-737, a small molecule Bcl-2/Bcl-xL antagonist, increases antimitotic-mediated apoptosis in human prostate cancer cells.

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The contract was highly standardised by means of the AB 04 and ABT 06 agreements, and through the AMA AF administrative provisions. This tradition has 

ABT-737 induces mitochondrial pathway apoptosis and mitophagy. Phase 2. Size. Price. 2007-04-26 · ABT-737 is a BH3 mimetic small-molecule inhibitor that binds with high affinity to Bcl-2 and Bcl-xL, preventing the sequestration of proapoptotic molecules and shifting the cell survival/apoptosis 2017-02-28 · ABT-737 is a small-molecule that acts as a selective inhibitor of Bcl-2. Bcl-2 proteins play an important role in cell survival and have been shown to be overexpressed in many tumors.

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Apoptosis induced by jak2 inhibition is mediated by bim and enhanced by the bh3 mimetic abt-737 in jak2 mutant human erythroid cells Inhibition of JAK2 

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View the review history for ABT-737, a small molecule Bcl-2/Bcl-xL antagonist, increases antimitotic-mediated apoptosis in human prostate cancer cells.

Abt 737

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Interiörbild. Ytterligare strukturbaserade förbättringar gav föreningen ABT-737, vilken binds med låg nanomolär affinitet till Bcl- xl, Bcl-2 och Bcl-w men inte till Mcl-1 eller Al. Cup Poly Arcom crosslinked non-flanged storl 28 x 48mm,Exceed ABT 737, Huvud, 1990, 00-8775-032-04, Biolox Delta Head, 12/14 32mm XL/ +7.0. Störning av denna interaktion med ABT-737 (BH3-mimetisk) inducerar autofagi (Maiuri et al, 2007).
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Find technical definitions and synonyms by letter for drugs/agents used to treat patients with cancer or conditions related to cancer. Each entry includes links to find associated clinical trials.

ABT-737 is a small-molecule BH3 mimetic that exhibits single-agent activity against lymphoma and small-cell lung cancer in preclinical studies. We here report that ABT-737 effectively kills acute myeloid leukemia bla …. BCL-2 proteins are critical for cell survival and are overexpressed in many tumors. ABT-737 is a small-molecule BH3 mimetic that BH3 mimetic ABT-737 induces apoptosis.